Mass Spectrometry Center

— A Leading Integrated Mass Spectrometry Solution

Alfa Chemistry has long been committed to providing high-quality analytical testing services to global scientific and industrial customers. As a core component of our analytical service system, the MS Center integrates advanced instrumentation platforms with multi-dimensional technical routes, aiming to deliver efficient, reliable, and precise molecular analysis solutions. Whether it’s quantitative detection of drug metabolites or structural elucidation of complex macromolecules, the MS Center offers fully customized services tailored to your needs.

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Explore Our Four Core Mass Spectrometry Technologies

Gas Chromatography-Mass Spectrometry (GC-MS)

Liquid Chromatography-Mass Spectrometry (LC-MS)

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Gel Permeation Chromatography-Mass Spectrometry (GPC-MS)

Gas Chromatography-Mass Spectrometry (GC-MS)

Ideal for thermally stable and volatile compounds, such as organic solvents, volatile pollutants, and pesticide residues. GC-MS is commonly used for qualitative and quantitative analysis in environmental samples, synthetic materials, and food matrices.

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Liquid Chromatography-Mass Spectrometry (LC-MS)

Optimized for polar or thermally unstable compounds. LC-MS excels in the analysis of drug metabolites, plant metabolites, and natural products, and is effective in complex matrix environments.

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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Offering higher selectivity and sensitivity, LC-MS/MS is ideal for trace-level quantitative analysis. It is widely applied in the targeted analysis of multi-component systems, including trace substances in biological samples, food, and agricultural products.

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Gel Permeation Chromatography-Mass Spectrometry (GPC-MS)

Combining the molecular weight separation capability of GPC with the sensitive detection of MS, GPC-MS is specifically designed for molecular weight distribution and structural analysis of polymers and biological macromolecules. This platform is widely used in the R&D and quality control of polymer materials, drug delivery systems, and biopolymers.

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Expert Analytical Services Powered by Advanced Mass Spectrometry

Small Molecule Analysis

The MS Center is widely used for the analysis of drugs, metabolites, pesticide residues, environmental pollutants, and other small molecules. We offer both highly sensitive quantitative detection at the ng/μL level and highly specific qualitative analysis.

Macromolecule Analysis

We provide molecular weight determination, structural elucidation, and sequence analysis for proteins, peptides, biopolymers, and other macromolecules, supporting research in biomedicine and material science.

Impurity and Structural Identification

Utilizing high-resolution mass spectrometry (HRMS), we can rapidly identify unknown impurities and degradation products and support structural elucidation with comprehensive spectral data.

Multi-Platform Integrated Analysis

The MS Center works in synergy with other platforms such as Nuclear Magnetic Resonance (NMR), ICP-MS, and HPLC, offering a full-spectrum analytical solution from molecular weight to atomic composition.

Industry Applications

Analysis of Plant Metabolites

Comprehensive identification and quantification of endogenous and exogenous metabolites in plant extracts, herbal medicines, and natural products.

Analysis of Organic Compounds

Structural confirmation and purity assessment of organic raw materials, synthetic intermediates, additives, and fine chemicals

Analysis of Pesticides

High-throughput screening and trace-level quantification of pesticide residues in food, drinking water, and environmental samples using GC-MS and LC-MS/MS.

Isolation and Identification of API Impurities

Utilizing LC-MS/MS and HRMS, we isolate, identify, and characterize potential impurities in APIs and finished drug products in accordance with ICH Q3A/B guidelines.

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Identification of Complex APIs in Generic Drugs

We identify and confirm complex or mixed-component APIs in generics through high-resolution MS, ensuring consistency with the reference listed drugs.

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Identification of Falsified Drugs and Counterfeit Drugs

Rapid identification of falsified or counterfeit drugs through high-throughput screening and fingerprint comparison of active ingredients.

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Why Choose Alfa Chemistry MS Center?

Multi-platform coverage (LC-MS, GC-MS, HRMS, MALDI-TOF)
High-sensitivity & high-resolution instrumentation
Extensive industry experience & application cases
Traceable data aligned with international standards
Fast turnaround & global customer service support

Sample Submission & Workflow

To ensure efficient project execution, Alfa Chemistry MS Center offers a complete sample submission workflow and online form system to streamline the process:

Pre-submission Guidelines

Before sending your samples, please refer to our official Mass Spectrometry Sample Submission Guidelines.

Online Submission Form

To submit your sample information and testing request, please fill out our official submission form.

Service Pricing & Quotations

Our pricing is transparently structured based on the selected platform, sample number, analysis complexity, and reporting format.

What Success Stories Can We Share?

Discover how our services are applied in real-world scenarios through our case studies.

Case 1: Plant Metabolite Profiling for a North American Herbal Supplement Company

Client Background

A US-based botanical supplement company sought to develop a new product based on Lonicera japonica (honeysuckle) extract. They needed full compositional profiling to enhance label transparency and meet FDA ingredient disclosure requirements.

Project Scope

Identify key plant metabolites (chlorogenic acids, flavonoids, phenylethanoid glycosides)
Determine distribution ratios for functional positioning
Provide English report with high-resolution spectra and compound list

Technical Approach

Comprehensive LC-MS profiling
MS/MS fragmentation analysis and comparison with standards
Printable English report provided for regulatory documentation and marketing

Outcome

Over 40 metabolites identified, including chlorogenic acid, luteoloside, and isochlorogenic acid
Supported formulation development and compliance
Report used in product registration and consumer labeling

Case 2: LC-MS/MS Analysis for Impurity Profiling in Generic Drug Development

Client Background

A generic pharmaceutical company preparing an ANDA (Abbreviated New Drug Application) required impurity profiling for donepezil hydrochloride API.

Project Scope

Quantify 3 known process-related impurities
Identify 1 unknown impurity
Provide full method validation report compliant with FDA standards

Technical Approach

Targeted LC-MS/MS quantification
HRMS structure elucidation for unknowns
Method validation per ICH Q3A guidelines (accuracy, linearity, LOD/LOQ)

Outcome

Unknown impurity identified as a demethylated byproduct (+14.015 Da)
Full validation report included quantitation curves, S/N ratios, and regulatory thresholds
Report incorporated into ANDA filing; approval process successfully advanced

Case 3: GC-MS Screening for Pesticide Residues in Strawberries

Client Background

A third-party food testing lab partnered with a major supermarket chain to conduct routine pesticide residue testing on strawberry samples.

Project Scope

Screen for 20+ target pesticides (e.g., dichlorvos, chlorothalonil, imidacloprid)
Meet EU MRL (Maximum Residue Limit) standards
Deliver rapid reports to support supplier quality assurance

Technical Approach

GC-MS analysis with QuEChERS sample preparation
In-house pesticide standard database for spectrum comparison
Internal standard method to ensure quantitative accuracy

Outcome

3 pesticides detected, all within regulatory limits
Full report delivered within 4 business days
Client extended long-term cooperation based on responsiveness and reliability

Frequently Asked Questions (FAQs)

Q1: What types of samples can you analyze?

We support a wide range of samples including solids, liquids, biological matrices, polymers, and more.

Q2: Can you provide reports in GLP or GMP-compliant formats?

Yes, we offer GLP/GMP-compliant documentation upon request.

Q3: How should I prepare my sample for submission?

We recommend referring to our sample submission guidelines and including detailed sample metadata.

Q4: What’s included in the data deliverables?

We provide raw MS spectra, quantitative analysis results, and structural elucidation reports.

Q5: Can you assist in unknown compound identification?

Absolutely. Our HRMS and MS/MS platforms are optimized for structure elucidation of unknowns.

Latest Updates

Stay informed with the latest updates from our company, where we continually innovate and enhance our services to meet your needs.

Development

Latest Mass Spectrometry Articles

Blog

Mastering Mass Spectrometry: A Comprehensive Guide for Beginners

Blog

The Use of Gel Permeation Chromatography-Mass Spectrometry (GPC-MS) for Polymer Analysis

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Mass Spectrometry Center

Explore Our Four Core Mass Spectrometry Technologies

Gas Chromatography-Mass Spectrometry (GC-MS)

Liquid Chromatography-Mass Spectrometry (LC-MS)

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Gel Permeation Chromatography-Mass Spectrometry (GPC-MS)

Expert Analytical Services Powered by Advanced Mass Spectrometry

Small Molecule Analysis

Macromolecule Analysis

Impurity and Structural Identification

Multi-Platform Integrated Analysis

Industry Applications

Analysis of Plant Metabolites

Analysis of Organic Compounds

Analysis of Pesticides

Pharma Support Services

Isolation and Identification of API Impurities

Identification of Complex APIs in Generic Drugs

Identification of Falsified Drugs and Counterfeit Drugs

Why Choose Alfa Chemistry MS Center?

Sample Submission & Workflow

Pre-submission Guidelines

Online Submission Form

Service Pricing & Quotations

What Success Stories Can We Share?

Case 1: Plant Metabolite Profiling for a North American Herbal Supplement Company

Case 2: LC-MS/MS Analysis for Impurity Profiling in Generic Drug Development

Case 3: GC-MS Screening for Pesticide Residues in Strawberries

Frequently Asked Questions (FAQs)

Latest Updates

Latest Mass Spectrometry Articles

Mastering Mass Spectrometry: A Comprehensive Guide for Beginners

The Use of Gel Permeation Chromatography-Mass Spectrometry (GPC-MS) for Polymer Analysis

Need Help or Have a Question?