Latest Nuclear Magnetic Resonance Spectroscopy Articles

Li, Y.; et al. Graphene quantum dot-based magnetic relaxation switch involving magnetic separation for enhanced performances of endoglin detection using ultra-low-field nuclear magnetic resonance relaxometry. Sensors and Actuators B: Chemical. 2023: 133389.

Introduction

In this study, the authors developed a magnetic separation-assisted MRS using iron oxide as a magnetic carrier and magnetic graphene quantum dots as a magnetic probe to detect endoglin. The assay possesses a broad linear region from 5 ng/mL to 50 μg/mL and a sensitive limit of detection of 1.3 ng/mL, which is two orders of magnitude lower than that of MRS without magnetic separation. The high accuracy and consistency have been proved for endoglin (CD105) detection in real samples. This graphene quantum dot-based MRS involving magnetic separation provides a new route for enhancing the sensitivity and accuracy of biomolecule detection.

Camdzic, D.; et al. Quantitation of total PFAS including trifluoroacetic acid with fluorine nuclear magnetic resonance spectroscopy. Analytical Chemistry. 2023.

Introduction

Fluorine nuclear magnetic resonance (¹⁹F-NMR) spectroscopy has been shown to be a powerful tool capable of quantifying the total per- and polyfluoroalkyl substances (PFAS) in a complex sample. The technique relies on the characteristic terminal −CF₃ shift (−82.4 ppm) in the alkyl chain for quantification and does not introduce bias due to sample preparation or matrix effects.

The authors report a sensitive ¹⁹F-NMR method for the analysis of total PFAS, with a limit of detection of 99.97 nM, or 50 μg/L perfluorosulfonic acid. The use of this method to quantify the total PFAS in highly complex samples can be used to complement classic TOP or LC-MS approaches for more accurate reporting of PFAS contamination in the environment.

Huang, C.; et al. Adaptable singlet-filtered nuclear magnetic resonance spectroscopy for chemical and biological applications. Analytical Chemistry. 2022, 94(10): 4201-4208.

Introduction

Proton nuclear magnetic resonance (¹H NMR) spectroscopy presents a powerful detection tool for studying chemical compositions and molecular structures. In practical chemical and biological applications, ¹H NMR experiments are generally confronted with the challenge of spectral congestions caused by abundant observable components and intrinsic limitations of a narrow frequency distribution range and extensive J coupling splitting.

The authors propose a one-dimensional (1D) general NMR method individually extract the signals of targeted proton groups based on their endogenous spin singlet states excited from J coupling interactions, and it is suitable for high-resolution detections on complex chemical and biological samples.

Wei, Y.; et al. Multi-nuclear magnetic resonance spectroscopy: state of the art and future directions. Insights into Imaging. 2022, 13(1): 135.

Introduction

Multi-nuclear magnetic resonance spectroscopy is an emerging technique. With the development of magnetic resonance software and hardware, multi-nuclear magnetic resonance imaging has been applied to the basic and clinical transformation of various systems of human.

This review aims to focus on the recent applications of multi-NMR technology not only in a range of preliminary animal experiments but also in various disease spectrum in human.

Du, J. H.; et al. Identification of CO₂ adsorption sites on MgO nanosheets by solid-state nuclear magnetic resonance spectroscopy. Nature communications. 2022, 13(1): 707.

Introduction

The detailed information on the surface structure and binding sites of oxide nanomaterials is crucial to understand the adsorption and catalytic processes and thus the key to develop better materials for related applications. However, experimental methods to reveal this information remain scarce.

The authors show that ¹⁷O solid-state nuclear magnetic resonance (NMR) spectroscopy can be used to identify specific surface sites active for CO₂ adsorption on MgO nanosheets.