Gel Permeation Chromatography Technology Platforms

Gel permeation chromatography (GPC), also known as size exclusion chromatography (SEC), is a valuable tool for the purification, separation and characterization of polymers. In general, the GPC system consists of porous beads (gels) in the column, a pump that moves the sample and eluent through the column, and a detector that detects when different analytes are eluted through the column (Fig. 1). In GPC technology, the analyte (usually a polymer) is often dissolved in a suitable solvent and injected into a column made of porous inert material. Chromatography columns separate analytes based on their hydrodynamic size rather than their molecular weight^[1].

Fig. 1 Main components of a GPC system

Alfa Chemistry is a professional testing and analysis organization with an experienced technical team that employs a state-of-the-art technology platform to meet the full range of our clients' gel permeation chromatography needs. Our technology platform can provide you with a wide range of services.

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GPC systems typically have a UV detector, RI detector, or light scattering unit attached to the columns. By combining advanced detection systems with GPC, we can obtain important information about polymers, including molecular weight distribution, polymer branching degree, and average molecular mass. In addition to separating polymers, GPC also allows for the separation of enzymes, polysaccharides, nucleic acids, and hormones, etc.

Gel permeation chromatography - Multi-Angle Static Light Scattering (GPC-MALS)

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Gel permeation chromatography - Infrared Spectroscopy (GPC-IR)

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Gel permeation chromatography - Mass Spectrometry (GPC-MS)

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At Alfa Chemistry, our expert analysts can provide you with improved quality services to support your business. Our specialized analytical platforms ensure consistently accurate and detailed delivery. Alfa Chemistry looks forward to cooperating with you.

Reference

1. Mohammad, A. K., & Reineke, J. Quantitative Nanoparticle Organ Disposition by Gel Permeation Chromatography. Nanotoxicity, 2012, 361–367.

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